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MIT-Portugal Bio-Engineering Systems:
Leaders in Technical Innovation

People - MIT Faculty - Lino Ferreira

Lino Ferreira lino@mit.edu

Education

2006-Present: Assistant Researcher, Center of Neurosciences and Cell Biology (CNC)/Biocant (Coimbra)

2004-Present: Postdoctoral Fellow, Massachusetts Institute of Technology (MIT)

2003-2004: Postdoctoral Fellow, Institute of Biomedical Engineering (University of Porto, Portugal)

1999-2003: Ph.D. in Chemical Engineering and Biotechnology (University of Coimbra, Portugal)

1995-1998: M.Sc. in Biochemistry (University of Coimbra, Portugal)

1989-1994: B.Sc. in Biochemistry (University of Coimbra, Portugal)

Research Interests: Biomaterials, Stem cell differentiation, Tissue engineering

Peer Reviewed Publications

1- Ferreira, L., Vidal, M.M., Geraldes, C.F.G.C., Gil, M.H. "Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate”, Carbohydrate Polymers 2000, 41(1), 15-24.

2- Ferreira, L., Vidal, M.M., Gil, M.H. “Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values”, International Journal of Pharmaceutics  2000, 194(2), 169-180.

3- Ferreira, L., Vidal, M.M., Gil, M.H. “Design of a drug-delivery system based on polyacrylamide hydrogels. Evaluation of structural properties”, Chem. Educator 2001, 6, 100-103.

4- Ferreira, L., Carvalho, R., Gil, M.H., Dordick, J.S. “Enzymatic synthesis of inulin-containing hydrogels”, Biomacromolecules 2002, 3, 333-341.

5- Ferreira, L., Gil M.H., Dordick, J.S. “Enzymatic synthesis of dextran-containing hydrogels”, Biomaterials  2002, 23, 3957-3967.

6- Ferreira, L., Kim, D.-Y., Carvalho, R., Geraldes, C.F.G.C., Gil, M.H., Dordick, J.S. “Biocatalytic polytransesterification of inulin with divinyladipate”, Chemistry of Materials 2002, 14(10), 4009-4011.

7- Ferreira, L., Ramos, M.A., Gil, M.H., Dordick, J.S. “Exquisite regioselectivity and transesterification activity enhancement of an immobilized Bacillus subtilis protease”. Biotechnology Progress 2002, 18(5), 986-993.

8- Ferreira, L., Ramos, M.A., Dordick, J.S., Gil, M.H. “Influence of different silica derivatives in the immobilization and stabilization of a Bacillus licheniformis protease (subtilisin Carlsberg)”, Journal of Molecular Catalysis B: Enzymatic 2003, 21, 189-199.

9- Ferreira, L., Rafael, A., Lamghari, M., Barbosa, M.A., Gil, M.H., Cabrita, A.M.S., Dordick, J.S. “Biocompatibility of  chemoenzymatically derived dextran hydrogels”, Journal of Biomedical Materials Research 2004, 68A, 584-596.

10- Ferreira, L., Gil, M.H., Cabrita, A.M.S., Dordick, J.S. “Biocatalytic synthesis of highly ordered biocompatible and degradable dextran-based hydrogels”, Biomaterials 2005, 26, 4707-4716.

11- Ferreira, L., Figueiredo, M.M., Gil, M.H., Ramos, M.A. “Structural analysis of dextran-based hydrogels obtained chemoenzymatically”, Journal of Biomedical Materials Research: part B (Applied Biomaterials) 2006, 77B:55-64.

12- Ferreira, L., Evangelista M.B., Martins M.C.L., Esteves, J.L., Barbosa, M.A. “Improving the adhesion of poly(ethylene terephthalate) fibers to poly(hydroxyethyl methacrylate) hydrogels by ozone treatment: surface characterization and pull-out tests.” Polymer 2005, 46, 9840-9850.

13- Maia, J., Ferreira, L., Carvalho, R., Ramos M.A., Gil, M.H. “Synthesis and characterization of new injectable and degradable dextran-based hydrogels.” Polymer 2005, 46, 9604-9614.

14- Jeffrey M. Karp, Lino S. Ferreira, Ali Khademhosseini, Albert H. Kwon, Judy Y. Yeh, Robert Langer. “Cultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitro”. Stem cells 2006, 24(4), 835-843.

15- Ferreira, L.*, Khademhosseini, A.*, Blumling, J, Yeh, J., Karp, J.M., Fukuda, J., Langer, R. “Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates”. Biomaterials 2006, 27, 5968- 5977 (*Authors contributed equally).

 

Book Chapters

1-Gil M.H., Duarte, M.G., Ferreira, L., Geraldes, C.F.G. “Polymeric Biomaterials”. In: Polymer Chemistry, Eds: Melo, J.S.S., Moreno, M.J., Burrows, H.D., Gil, M.H. Coimbra University Press, Coimbra, 2004, p. 641-664.

2- Ferreira*, L., Khademhosseini*, A., Karp*, J.M., Gerecht-Nir*, S., Vunjak-Novakovic, G., Langer, R. “Embryonic stem cells as a cell source for tissue engineering. In “Principles of Tissue Engineering- 3rd edition”. Editors: Lanza, R., Langer, R., Vacanti, J.P. Elsevier/Academic Press, 2006 (in press). (Authors contributed equally)

3- Luo, Y., Ferreira, L., Langer, R. “Three-dimensional scaffolds”. In “Principles of Tissue Engineering- 3rd edition”. Editors: Lanza, R., Langer, R., Vacanti, J.P. Elsevier/Academic Press, 2006 (in press).

4- Jeffrey M. Karp, Lino S. Ferreira, Ali Khademhosseini, Robert Langer. “In vitro differentiation of human embryonic stem cells along osteogenic pathways”. To be published in book “Human embryonic stem cells: a practical approach”. John Wiley Press, 2006.

Patents / Technology Disclosures

1-Karp, J.M., Ferreira, L.S., Khademhosseini, A., Langer, R.S. “Amplification of specific cell populations from human embryonic stem cells”. Patent pending, 2005

2- Zumbuehl, A., Ferreira, L.S., Kohane, D.S., Fink, G.R., Langer, R.S. “Prophylaxis of fungal infections”. Patent pending, 2005.

3- Ferreira, L.S., Gerecht-Nir, S., Vunjak-Novakovic, G., Langer, R.S. “Vascular progenitor cells isolated from human embryonic stem cells”. Patent pending, 2005.

4- Nijst, C., Karp, J.M., Joost, J., Ferreira, L., Zumbuehl, A., Bettinger, C., Langer, R. “Development of Multifunctional Photocurable Degradable Elastomers”. U.S. Provisional Patent Application pending, 2006.

5- Ferreira, L.S., Khademhosseini, A., Karp, J.M., Yeo, Y., Langer, R. “Highly Efficient regenerative desiccant materials.” Patent pending, 2006.